Back to results
US 12,617,858 B2Granted
Anti-Müllerian hormone receptor 2 antibodies and methods of use
AssigneeThe Cleveland Clinic Foundation
InventorsVincent K. Tuohy, Suparna Mazumder, Justin M. Johnson
Life of this patent
Estimating the term…
Abstract
Provided herein are anti-Anti-Müllerian Hormone Receptor 2 (AMHR2) antibodies and methods of using such antibodies, for example, in the treatment of cancer.
Claims16
An isolated antibody, wherein said antibody comprises a heavy chain comprising a variable heavy (VH) chain sequence comprising three heavy chain CDR sequences, CDR-H1, CDR-H2, and CDR-H3, and a light chain comprising a variable light (VL) chain sequence comprising three light chain CDR sequences, CDR-L1, CDR-L2, and CDR-L3, wherein
- a) CDR-H1 comprises the sequence shown in SEQ ID NO:
- 1,
- b) CDR-H2 comprises the sequence shown in SEQ ID NO:
- 2,
- c) CDR-H3 comprises the sequence shown in SEQ ID NO:
- 3,
- d) CDR-L1 comprises the sequence shown in SEQ ID NO:
- 4,
- e) CDR-L2 comprises the sequence shown in SEQ ID NO:
- 5, and
- f) CDR-L3 comprises the sequence shown in SEQ ID NO:
- 6.
9 more elements
An isolated polynucleotide or set of polynucleotides encoding:
- a) an antibody that comprises a heavy chain comprising a variable heavy (VH) chain sequence comprising three heavy chain CDR sequences, CDR-H1, CDR-H2, and CDR-H3, and a light chain comprising a variable light (VL) chain sequence comprising three light chain CDR sequences, CDR-L1, CDR-L2, and CDR-L3, wherein:
- i) CDR-H1 comprises the sequence shown in SEQ ID NO:
- 1,
- ii) CDR-H2 comprises the sequence shown in SEQ ID NO:
- 2,
- iii) CDR-H3 comprises the sequence shown in SEQ ID NO:
- 3,
- iv) CDR-L1 comprises the sequence shown in SEQ ID NO:
- 4,
- v) CDR-L2 comprises the sequence shown in SEQ ID NO:
- 5, and
- iv) CDR-L3 comprises the sequence shown in SEQ ID NO:
- 6,
- b) a VH of said antibody,
- c) a VL of said antibody,
- d) a light chain of said antibody,
- e) a heavy chain of said antibody, or
- f) an antigen-binding portion of said antibody.
15 more elements
Dependencies are inferred from the claim text.