Method of treating glomerulonephritis by administering an antibody which binds and neutralizes human TGF-Beta1, TGF-Beta2 and TGF-Beta3

A method of treating glomerulonephritis in a patient in need thereof, comprising administering to the patient an effective amount of an isolated specific binding member that binds to and neutralizes human TGFβ1, TGFβ2, and TGFβ3, the binding member comprising an antigen-binding domain of an antibody,

• wherein a variable domain of the heavy chain (VH) of the antibody comprises
• an HCDR1 comprising the amino acid sequence of SEQ ID NO:
• 3,
• an HCDR2 comprising the amino acid sequence of SEQ ID NO:
• 4, and
• an HCDR3 comprising the amino acid sequence of SEQ ID NO:
• 5;
• and
• wherein a variable domain of the light chain (VL) of the antibody comprises
• an LCDR1 comprising the amino acid sequence of SEQ ID NO:
• 8,
• an LCDR2 comprising the amino acid sequence of SEQ ID NO:
• 9, and
• an LCDR3 comprising the amino acid sequence of SEQ ID NO:
• 10.