IL-36 cytokine expressing oncolytic viruses for treating cancer
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsZong Sheng Guo, Binfeng Lu, David L. Bartlett
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Abstract
The present disclosure provides interleukin-36 (IL-36) cytokine (e.g., IL-36γ) expressing oncolytic viruses, and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent.
Claims11
An oncolytic vaccinia virus comprising a recombinant nucleic acid molecule encoding interleukin-36γ (IL-36γ), wherein the oncolytic vaccinia virus lacks the expression of a functional thymidine kinase (TK), wherein the recombinant nucleic acid molecule is operably linked to a promoter.
Dependencies are inferred from the claim text.