Therapeutic agent of peripheral blood flow disorder

A method for treating a peripheral blood flow disorder, the method comprising:

• intravenously administering, to a patient in need thereof, a therapeutically effective amount of an SSEA-3-positive pluripotent stem cell which is a Muse cell isolated or enriched from a mesenchymal tissue in a living body or a cultured mesenchymal cell comprising mesenchymal stem cells,
• wherein the SSEA-3-positive pluripotent stem cell is isolated from the mesenchymal tissue in the living body or the cultured mesenchymal cell by using an antigenic marker SSEA-3 as an index or enriched from the mesenchymal tissue in the living body or the cultured mesenchymal cell by culturing under external stress condition, and
• wherein the SSEA-3-positive pluripotent stem cell is one having all of the following characteristics:
• (i) having low telomerase activity;
• (ii) capable of differentiating into any of tridermic cells;
• (iii) showing no neoplastic proliferation;
• and
• (iv) having self-renewal capacities, and
• wherein the method increases expression of CD31 and improves ischemic state in the patient, as compared to when non-Muse cells which are remaining stem cells obtained by isolating the SSEA-3-positive pluripotent stem cell from the mesenchymal stem cells are administered.