Prospective markers in traumatic brain injury (TBI)

A method for treating a subject having experienced a mild traumatic brain injury (TBI) comprising the steps of:

• a) determining the levels of IL-10 and H-FABP in one or more samples of the subject;
• b) comparing each level obtained under step a) with a corresponding reference value to determine an unfavorable recovery outcome, wherein the unfavorable recovery outcome is characterized by a level of IL-10>0.388 pg/mL and a level of H-FABP>4.305 ng/mL in the one or more samples of the subject;
• and
• c) treating the subject having the unfavorable recovery outcome under step b) with a neuroprotective agent or hypothermia;
• wherein the unfavorable recovery outcome under step b) is assessed by a score of four (4) or less in accordance with the Glasgow Outcome Scale Extended (GOSE);
• and wherein the method is performed on the one or more samples which are taken, independently, less than 24 hours after occurrence of the mild TBI.