Detection of biomarkers for non-small cell lung cancer
AssigneesSengenics Sdn Bhd, National University of Singapore
InventorsJonathan Michael Blackburn, Arif Anwar, Boon Cher Goh, Lingzhi Wang, Sok Hwee Esther Cheow, Ross Andrew Soo, Win Lwin Thuya
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Abstract
A method for diagnosing Non-Small Cell Lung Cancer (NSCLC) from a sample extracted from a subject by testing the sample for the presence of biomarkers, the biomarkers being autoantibodies against XAGE1D, LRRFIP2 and GAGE2C. Also claimed are a method of manufacturing a kit, and compositions comprising a panel of said antigens or exosomal autoantibodies.
Claims19
A composition comprising a panel of antigens comprising biotinylated proteins, wherein the biotinylated proteins consist of X Antigen Family Member 1D (XAGE1D), LLR Binding FLII Interacting Protein 2 (LRRFIP2), G Antigen 2C (GAGE2C), MAGE Family Member A10 (MAGEA10), Signal Transducer and Activator of Transcription 1 (STAT 1), Zinc Ribbon Domain-Containing 1 (ZNRD1), and RAD23 Homolog B (RAD23B).
A composition for detecting non-small cell lung cancer, which comprises a panel of antigens bound to a substrate, wherein the antigens consist of X Antigen Family Member 1D (XAGE1D), LLR Binding FLII Interacting Protein 2 (LRRFIP2), G Antigen 2C (GAGE2C), MAGE Family Member A10 (MAGEA 10), Signal Transducer and Activator of Transcription 1 (STAT 1), Zinc Ribbon Domain-Containing 1 (ZNRD 1), and RAD23 Homolog B (RAD23B).
A composition for detecting non-small cell lung cancer, which comprises a panel of antigens comprising biotinylated proteins, wherein the biotinylated proteins consist of X Antigen Family Member 1D (XAGE1D), LLR Binding FLII Interacting Protein 2 (LRRFIP2), G Antigen 2C (GAGE2C), MAGE Family Member A10 (MAGEA 10), Signal Transducer and Activator of Transcription 1 (STAT 1), Zinc Ribbon Domain-Containing 1 (ZNRD 1), and RAD23 Homolog B (RAD23B).
Dependencies are inferred from the claim text.