US 12,601,704 B2 · System and method for measurement of ion concentration in fluid samples

Abstract

A signal is obtained which comprises voltage measurements obtained from the calibration fluid and voltage measurements obtained from the unknown fluid. Diffusion of the measurements during the transition from measuring the calibration fluid to measuring the unknown fluid is modelled using a first model. The drift of the measurements is modelled from the calibration fluid measurements using a second model. The first model identifies a value and corresponding time point at which the diffusion process has settled. A calibration voltage value is estimated at the corresponding time point and the difference between the identified value and the calibration electrical potential value is calculated to determine a voltage difference. This voltage difference is normalized by adjusting the difference by a shift amount determined in relation to the calibration electrical potential value and a predetermined voltage value. The normalized voltage is then used to determine the ion concentration of the unknown fluid.

Claims20

Dependent claims

A device for measurement of ion concentration in fluid samples, the device comprising:

a sensor assembly configured to obtain voltage measurements from a fluid sample passing thereover;
and
a control unit comprising one or more processors configured to:
obtain, from the sensor assembly, a signal comprising a calibration portion and a sampling portion, the calibration portion comprising voltage measurements obtained from a calibration fluid passing over the sensor during a first time period and the sampling portion comprising voltage measurements obtained from an unknown fluid passing over the sensor during a second time period;
fit a first model to the sampling portion of the signal to identify a first time point associated with a settled voltage value determined from the first model;
fit a second model to the calibration portion of the signal to identify a calibration voltage value from the second model at the first time point;
determine a voltage difference between a voltage value of the sampling portion at the first time point and the calibration voltage value;
shift the voltage difference by a shift amount to determine a normalized voltage difference, the shift amount corresponding to a difference between the calibration voltage value and a predetermined voltage value;
and
calculate an ion concentration of the unknown fluid based on the normalized voltage difference.

7 more elements

A computer-implemented method for measurement of ion concentration in fluid samples, the computer-implemented method comprising:

obtaining a waveform comprising a calibration portion and a sampling portion, the calibration portion comprising electrical potential measurements obtained from a calibration fluid passing over a sensor during a first time period and the sampling portion comprising electrical potential measurements obtained from an unknown fluid passing over the sensor during a second time period;
fitting a diffusion model to the sampling portion of the waveform to identify a first time point associated with a settled electrical potential value determined from the diffusion model;
fitting a drift model to the calibration portion of the waveform to identify a calibration electrical potential value from the drift model at the first time point;
determining an electrical potential difference between the settled electrical potential value and the calibration electrical potential value;
normalizing the electrical potential difference by shifting the electrical potential difference by an offset value thereby generating a normalized electrical potential difference, wherein the offset value corresponds to a difference between the calibration electrical potential value and a fixed electrical potential value;
and
calculating an ion concentration of the unknown fluid based on the normalized electrical potential difference.

4 more elements

Dependencies are inferred from the claim text.

System and method for measurement of ion concentration in fluid samples

Life of this patent

System and method for measurement of ion concentration in fluid samples

Life of this patent

Abstract

Claims20