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US 12,601,088 B2Granted
Detection of an antibody against a pathogen
AssigneesThe Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
InventorsStephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
Life of this patent
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Abstract
Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
Claims5
A method for detecting an antibody against a pathogen in a subject, the method comprising:
- (a) contacting a reaction sample comprising a display library with a biological sample comprising antibodies, wherein the display library comprises a plurality of peptides derived from a plurality of pathogens, wherein the display library is constructed using a synthetic, programmable microarray from a starting library that is uniformly distributed, and
- (b) detecting a peptide bound to at least one antibody, thereby detecting an antibody capable of binding the peptide.
Dependencies are inferred from the claim text.