CpG ODN having immunoregulatory function and use thereof
AssigneeParr Biotechnology (Hebei) Co., Ltd.
InventorsLigong Wang, Yan Shao
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Abstract
Provided are an immunomodulatory CpG ODN chemically modified by means of a structure as shown by general formula I and the use thereof. The CpG ODN has an immunostimulatory activity, can stimulate the proliferation of B cells, and produce specific cytokines. The above-mentioned CpG ODN can be used as a vaccine adjuvant alone or in combination with other adjuvants to exert a synergistic effect, and can also be used in the preparation of drugs for preventing or treating tumors, infections, and allergies.
Claims22
An immunoregulatory CpG ODN with a maximum length of 26 bp comprising a nucleotide sequence selected from SEQ ID NOs:
- 1-4 and 6, wherein at least one nucleotide in the nucleotide sequence is a phosphorothioated nucleotide.
Dependencies are inferred from the claim text.