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US 12,600,967 B2Granted
SiRNA compound that inhibits complement factor B (CFB)
AssigneeSirnaomics, Inc.
InventorDmitry Samarsky
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Abstract
Nucleic acid products that modulate, in particular interfere with or inhibit CFB gene expression, are provided. The products may be oligomeric compounds that comprise at least a first region of linked nucleosides having at least a first nucleobase sequence that is at least partially complementary to at least a portion o 5 f RNA transcribed from a CFB gene, where the first nucleobase sequence is selected from SEQ ID NOs 1 to 391, 751 and 752, or a fragment thereof.
Claims9
An siRNA compound that inhibits complement factor B (CFB), comprising
- (a) a first nucleobase sequence that is SEQ ID NO:251 linked directly to a second nucleobase sequence that is SEQ ID NO:503, or
- (b) a first nucleobase sequence that is SEQ ID NO:252 linked directly to a second nucleobase sequence that is SEQ ID NO:504;
- wherein said compound is 30 or 33 nucleosides long,
- wherein optionally at least one sugar in the siRNA is modified, and
- wherein optionally at least one internucleoside linkage is modified.
2 more elements
Dependencies are inferred from the claim text.