Compound for treatment of heart failure

An oligonucleotide comprising a sequence of formula III:

• 5′-dA*+T*dG*+G*dC*+T*dG*+T*dA*+G*dA*dC*dT*dG*+T*+T-3′ (SEQ ID NO:
• 3)
• wherein dA is 2′-deoxyadenosine, dG is 2′-deoxyguanosine, dC is 2′-deoxycytidine and T is thymidine, wherein +T is an LNA-T building block and +G is an LNA-G building block, and wherein * is a phosphorothioate linkage,
• the oligonucleotide being conjugated to a heterologous moiety, wherein the heterologous moiety is a lipid moiety.