Anti-IgG nanobodies
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsDirk Görlich, Tino Pleiner
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Abstract
The present invention relates to novel anti-IgG nanobodies, particularly nanobodies directed against rabbit or mouse IgG. Further, the invention relates to the use of said nanobodies and methods for producing them.
Claims11
A combination comprising a plurality of different single domain antibodies or a plurality of different immune complexes comprising a single domain antibody bound to an IgG antibody, wherein the single domain antibodies are selected from a combination of several single domain antibodies recognizing the same type of IgG molecules, which bind to non-overlapping epitopes on said IgG molecules,
- wherein the single domain antibodies are selected from:
- (i) single domain antibodies directed against rabbit IgG of SEQ ID NOs. 1 or 2;
- or
- (ii) single domain antibodies directed against mouse IgG of SEQ ID NOs. 3-34.
A combination comprising a plurality of different single domain antibodies or a plurality of different immune complexes comprising a single domain antibody bound to an IgG antibody, wherein the single domain antibodies are selected from a combination of several single domain antibodies recognizing the same type of IgG molecules, which bind to non-overlapping epitopes on said IgG molecules,
- wherein at least one single domain antibody of said combination
- (i) is directed against rabbit IgG of SEQ ID NOs. 1 or 2;
- or
- (ii) is directed against mouse IgG of SEQ ID NOs. 3-34.
A combination comprising a plurality of different single domain antibodies comprising a single domain antibody bound to an IgG antibody, wherein the single domain antibodies are selected from a combination of several single domain antibodies recognizing the same type of IgG molecules, which bind to non-overlapping epitopes on said IgG molecules,
- wherein the single domain antibodies are selected from a combination of:
- (i) the single domain antibodies comprising amino acid sequences of SEQ ID NO. 5 and SEQ ID NO. 8;
- (ii) the single domain antibodies comprising the amino acid sequence of SEQ ID NO. 8 and SEQ ID NO. 19;
- (iii) the single domain antibodies comprising the amino acid sequences of SEQ ID NO. 18 and SEQ ID NO. 19;
- (iv) the single domain antibodies comprising the amino acid sequences of SEQ ID NO. 5 and SEQ ID NO. 18;
- (v) the single domain antibodies comprising the amino acid sequences of SEQ ID NO. 5 and SEQ ID NO. 25;
- or
- (vi) the single domain antibodies comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2.
Dependencies are inferred from the claim text.