Bispecific antibody, preparation method therefor and application thereof
AssigneeExcelmab, Inc.
InventorsWenjun Zhang, Feng Li, Yanan Hua, Jiaxi Liu, Chunhua Fang
Life of this patent
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Abstract
Provided are a bispecific antibody and a preparation method therefor. The antibody comprises structural domains capable of binding to CD20 and CD3, and a heterodimer Fc region. The structural domains capable of binding to CD20 and CD3 are each independently selected from a Fab region, a ScFv region, or an sDab region. The bispecific antibody targets CD20 and CD3, and mediates T cell-specific killing of tumor cells.
Claims12
A bispecific antibody, comprising a domain capable of binding to CD20, a domain capable of binding to CD3 and a heterodimeric Fc region, wherein the domain capable of binding to CD20 is selected from the group consisting of a Fab region, a scFv region and a sDab region;
- wherein the domain capable of binding to CD3 comprises a first immunoglobulin Fab region, wherein the first immunoglobulin Fab region is formed by a first heavy chain and a first light chain binding to each other, wherein a variable region of the heavy chain has the amino acid sequence as set forth in SEQ ID NO:
- 8, and a variable region of the light chain has the amino acid sequence as set forth in SEQ ID NO:
- 10;
- and the heterodimeric Fc region is composed of two polypeptide chains, wherein each of the polypeptide chains contains opposite-charged amino acid modifications.
Dependencies are inferred from the claim text.