Variant antibody that binds CD38
AssigneeVivasor, Inc.
InventorsBarbara A. Swanson, Heyue Zhou, Jian Cao
Life of this patent
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Abstract
The present disclosure provides anti-CD38 IgG class antibody having improved ability to be manufactured at higher yields compared to the parent antibody having the original wild type sequence. The present disclosure provides a mutated antibody light chain that reduces cleavage heterogeneity for improved production of a homogeneous population of antibody light chains.
Claims19
An antigen binding protein that binds CD38, comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises the sequence of SEQ ID NO:
- 1 and the light chain variable region comprises the sequence of SEQ ID NO:
- 3.
A fully human antibody of an IgG class or antibody Fab fragment thereof, comprising a heavy chain comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:1, and a light chain comprising a light chain variable region having the amino acid sequence of SEQ ID NO:3.
A nucleic acid encoding an antibody light chain comprising a light chain variable region having the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.