Anti-New York esophageal squamous cell carcinoma 1 (NY-ESO-1) antigen-binding proteins and methods of use thereof

An isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular binding domain that specifically binds to a conformational epitope of an HLA-A2 presented New York esophageal squamous cell carcinoma 1 peptide (NY-ESO-1 peptide), a transmembrane domain, and an intracellular signaling domain,

• wherein the extracellular binding domain is an antibody, or antigen-binding portion thereof, comprising a heavy chain variable region (HCVR) comprising a heavy chain complementarity determining region (HCDR) 1 of SEQ ID NO:
• 4, an HCDR2 of SEQ ID NO:
• 6, an HCDR3 of SEQ ID NO:
• 8, and a light chain variable region (LCVR) comprising a light chain complementarity determining region (LCDR) 1 of SEQ ID NO:
• 12, an LCDR2 of SEQ ID NO:
• 14, and an LCDR3 of SEQ ID NO:
• 16.