Rage antibodies, fragments and uses thereof
AssigneesThe Research Foundation for The State University of New York, The Regents of the University of California
InventorsDing Xu, Jeffrey Esko, Miaomiao Li
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Abstract
Provided are antibodies specific for the heparan sulfate binding site of Receptor for Advanced Glycation Endproducts (RAGE). Also provided are methods for treating of conditions in which RAGE is involved comprising administration of the antibodies to an individual in need of treatment.
Claims4
An isolated antibody that binds to heparin sulfate binding site of Receptor for Advanced Glycation Endproducts (RAGE) on a cell and does not interfere with the binding of RAGE ligands to RAGE on the cell, said antibody comprising a variable light chain (VL) and a variable heavy chain (VH), and wherein CDRL1 comprises the sequence denoted in SEQ ID NO:
- 1, the CDRL2 comprises the sequence demoted by SEQ ID NO:
- 2, the CDRL3 comprises the sequence denoted by SEQ ID NO:
- 3, the CDRH1 comprises the sequence denoted by SEQ ID NO:
- 4, the CDRH2 comprises the sequence denoted by SEQ ID NO:
- 5, and the CDRH3 comprises the sequence denoted by SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.