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US 12,600,773 B2Granted
Treatment of diuretic resistant heart failure patients having at least one copy of the TMPRSS6 rs855791 allele
AssigneesNovo Nordisk A/S, Yale University
InventorsJeffrey Testani, Veena Rao, Rahul Kakkar, Madhav N. Devalaraja, Chih-Hung Lo
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Abstract
The present disclosure provides methods of treating diuretic resistance by administering an IL-6 antagonist to patients who require diuresis. In typical embodiments, the patient has heart failure. Optionally, the patient has elevated urine levels of IL-6, plasma levels of IL-6, or both urine and plasma levels of IL-6.
Claims10
A method of treating a patient with diuretic resistant heart failure having at least one copy of the TMPRSS6 rs855791 allele who requires diuresis but is resistant to diuretics, comprising:
- administering, in combination with a diuretic, a therapeutically effective amount of an IL-6 antagonist to the patient.
Dependencies are inferred from the claim text.