Antigen-binding proteins targeting coronavirus (COV) variants
AssigneeInternational Business Machines Corporation
InventorsBinquan Luan, Leili Zhang, Tien Huynh
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Abstract
Techniques regarding antigen-binding proteins that can bind to CoV (e.g., SARS-CoV-2) variants are provided. For example, one or more embodiments described herein can comprise an antigen-binding protein that can comprise a heavy polypeptide chain variable region with an amino acid sequence that is a variant of SEQ ID NO: 7. The amino acid sequence can comprise at least one amino acid substitution selected from the group consisting of: R50D, R50E, R50W, R50F, R50Y, R50L, R50V, R50I, R50Pho, I54D, I54E, I54W, I54F, I54Y, I54Pho, L55D, L55E, L55W, L55F, L55Y, and L55Pho.
Claims14
An antigen-binding protein, comprising:
- a heavy polypeptide chain variable region with a first amino acid sequence that comprises SEQ ID NO:
- 10;
- and
- a light polypeptide chain variable region with a second amino acid sequence that is selected from the first group consisting of SEQ ID NO:
- 18 and SEQ ID NO:
- 19.
An antigen-binding protein, comprising:
- a heavy polypeptide chain variable region with a first amino acid sequence that comprises SEQ ID NO:
- 10;
- and
- a light polypeptide chain variable region with a second amino acid sequence that comprises SEQ ID NO:
- 18.
An antigen-binding protein, comprising:
- a heavy polypeptide chain variable region with a first amino acid sequence that comprises SEQ ID NO:
- 10;
- and
- a light polypeptide chain variable region with a second amino acid sequence that comprises SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.