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AssigneeHalozyme Hypercon, Inc.
InventorsPaul Brown, Tyler L Carter, Lyndon Fitzgerald Charles, Jr., Chase Spenser Coffman, Daniel Benjamin Dadon, Lisa Liu, Sadiqua Shadbar, Chaitanya Sudrik, Yi Tang, Shankul Vartak
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The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.
A pharmaceutically effective composition comprising particles suspended in a carrier comprising fatty acid esters, wherein a plurality of the particles comprise at least one antibody or a fragment thereof, wherein the total weight percent of the at least one antibody or the fragment thereof in the plurality of particles is greater than 65%, and wherein the composition further comprises a hyaluronan degrading agent.
A pharmaceutically effective composition comprising particles suspended in a carrier comprising ethyl oleate, wherein a plurality of the particles comprise at least one antibody or fragment thereof, and have diameters in the range of 10 μm to 50 μm, wherein the total weight percent of the at least one antibody or fragment thereof in the plurality of particles is greater than 65%, wherein the concentration of the at least one antibody or the fragment thereof in the composition is from 300 mg/mL to 650 mg/mL, and wherein the composition further comprises a hyaluronan degrading agent.
Dependencies are inferred from the claim text.