Modulators of the integrated stress response pathway

A compound of formula (I)

• or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein:
• R1 is H or C1-4 alkyl, wherein C1-4 alkyl is optionally substituted with one or more halogen, which are the same or different;
• R2 is H, F or C1-4 alkyl, wherein C1-4 alkyl is optionally substituted with one or more halogen, which are the same or different;
• R2a is H;
• R3 is phenyl or 6 membered aromatic heterocyclyl, wherein R3 is optionally substituted with one or more R7, which are the same or different;
• R7 is halogen, CN, C(O)OR8, OR8, C(O)R8, C(O)N(R8R8a), S(O)2N(R8R8a), S(O)N(R8R8a), S(O)2R8, S(O)R8, N(R8)S(O)2N(R8aR8b), SR8, N(R8R8a), NO2, OC(O)R8, N(R8)C(O)R8a, N(R8)S(O)2R8a, N(R8)S(O)R8a, N(R8)C(O)OR8a, N(R8)C(O)N(R8aR8b), OC(O)N(R8R8a), C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are optionally substituted with one or more R9, which are the same or different;
• R8, R8a, R8b are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are optionally substituted with one or more halogen, which are the same or different;
• R9 is halogen, CN, C(O)OR10, OR10, C(O)R10, C(O)N(R10R10a), S(O)2N(R10R10a), S(O)N(R10R10a), S(O)2R10, S(O)R10, N(R10)S(O)2N(R10aR10b), SR10, N(R10R10a), NO2, OC(O)R10, N(R10)C(O)R10a, N(R10)SO2R10a, N(R10)S(O)R10a, N(R10)C(O)N(R10aR10b), N(R10)C(O)OR10a or OC(O)N(R10R10a);
• R10, R10a, R10b are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are optionally substituted with one or more halogen, which are the same or different;
• R4 is H, C(O)OC1-4 alkyl or C1-4 alkyl, wherein C(O)OC1-4 alkyl and C1-4 alkyl are optionally substituted with one or more substituents selected from the group consisting of halogen, OH and O—C1-3 alkyl, wherein the substituents are the same or different;
• R4a, R4b, R4c, R5 are independently selected from the group consisting of H, halogen and C1-4 alkyl;
• and
• R4d, R4e are independently selected from the group consisting of H, OH, OC1-4 alkyl, halogen and C1-4 alkyl;
• or R4 and one of R4d and R4e form a methylene or ethylene group;
• or R4 and R4c form an ethylene group;
• or R4b and R4d form a covalent single bond;
• R6 is 7 to 12 membered heterobicyclyl, wherein R6 is optionally substituted with one or more R11, which are the same or different;
• R11 is R12, OH, OR12, halogen or CN;
• R12 is cyclopropyl, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein R12 is optionally substituted with one or more R13, which are the same or different;
• R13 is halogen, CN or OR14;
• and
• R14 is H or C1-4 alkyl, wherein C1-4 alkyl is optionally substituted with one or more halogen, which are the same or different.