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US 12,600,712 B2Granted
Amino-pyrimidine amides
AssigneeHoffmann-La Roche Inc.
InventorsAngelica Beurier, Michail Konstantinos Bogdos, Luke Green, Christian Kramer, Dmitry Mazunin, Emmanuel Pinard, Hasane Ratni
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Abstract
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein, compositions including the compounds and methods of using the compounds.
Claims11
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof, wherein:
- R1, R2, and R3 are independently selected from the group consisting of
- i) H,
- ii) C1-6-alkyl,
- iii) C2-6-alkynyl,
- iv) halogen,
- v) halo-C1-6-alkyl,
- vi) halo-C1-6-alkoxy,
- vii) cyano, and
- viii) cyano-C1-6-alkyl,
- wherein at least one of R1 and R3 is other than H;
- R4 and R5 are independently selected from the group consisting of
- i) H,
- ii) C1-6-alkyl,
- iii) halogen, and
- iv) halo-C1-6-alkyl,
- or R4 and R5 together with the carbon atom to which they are attached form a heterocycloalkyl or a substituted C3-8-cycloalkyl, wherein the substituted C3-8-cycloalkyl is substituted with R6 and R7;
- and
- R6 and R7 are independently selected from the group consisting of halogen, hydroxy, and C1-6-alkyl.
16 more elements
Dependencies are inferred from the claim text.