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US 12,600,698 B2Granted
Kinase inhibitors
AssigneeVidya Therapeutics, Inc.
InventorsCraig A. Coburn, Daniel J. Buzard, Dange Vijay Kumar
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Abstract
Disclosed herein, are protein kinase inhibitors, in particular Bruton tyrosine kinase (BTK) inhibitors, pharmaceutical compositions comprising them, processes for preparing them and uses of the inhibitors to treat or prevent diseases, disorders and conditions associated with kinase function. In particular, the present invention relates to CNS penetrable BTK inhibitors.
Claims21
A compound having the structure of Formula 1-C-(1S,3R) or Formula 1-C-(1R,3R):
- or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, racemate or isotope thereof, wherein:
- RB is H or Me;
- RC is —CH—CH2 or —C≡C—CH3;
- RA is
- wherein
- RA1 is —F or —Cl;
- and
- RA2 is H or F.
5 more elements
Dependencies are inferred from the claim text.