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US 12,599,701 B2Granted
Drug delivery system and methods of using the same
AssigneeAxogen Corporation
InventorsKasra Tajdaran, Justin Deuerling, Angelo Scopelianos, Robert C. Diluccio
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Abstract
A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.
Claims16
A method of preparing an implantable biomaterial, comprising:
- combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand;
- melting the polymer while the polymer is inside of an extruder having an extruder screw;
- in a first extrusion, extruding the combined polymer and the neuro-regenerative agent or the immunosuppressive agent with the extruder to form a first biomaterial having a first concentration of the neuro-regenerative agent or the immunosuppressive agent;
- and
- in a second extrusion, extruding the first biomaterial and additional polymer to form the implantable biomaterial with a second concentration of the neuro-regenerative agent or the immunosuppressive agent.
2 more elements
Dependencies are inferred from the claim text.