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US 12,599,677 B2Granted
Targeted PH sensitive liposomes
AssigneeNorthwestern University
InventorsLeo I. Gordon, Dong-Hyun Kim, Shuo Yang, Wooram Park, Taehoon Sim
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Abstract
Disclosed herein are synthetic nanoparticles, pharmaceutical compositions, kits, or methods for treating and/or preventing cancer. In some embodiments, the synthetic nanoparticles and/or pharmaceutical compositions comprises a pH sensitive liposome, an apolipoprotein, and andrographolide or derivative thereof. In some embodiments, the synthetic nanoparticles are delivered to a subject for treatment of cancer. In some embodiments, the cancer is T-cell lymphoma or B-cell lymphoma.
Claims18
A synthetic nanoparticle comprising:
- a pH sensitive liposome comprising a lipid layer comprising at least one pH sensitive (a) lipid;
- (b) an apolipoprotein in contact with the lipid layer;
- and
- (c) a drug having a low water solubility encapsulated within the liposome;
- and wherein the pH sensitive liposome comprises octadecylamine-p (API-L-ASP) 10 (“pH-ADT”).
2 more elements
Dependencies are inferred from the claim text.