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US 12,599,609 B2Granted
Methods of treating fuchs endothelial corneal dystrophy after descemetorhexis
AssigneeKowa Company, Ltd.
InventorsGary Gordon, Kazuhito Suehira
Life of this patent
Estimating the term…
Abstract
Methods for treating Fuchs endothelial corneal dystrophy (“FECD”), and medications that promote healing in FECD patients following descemetorhexis.
Claims26
A method of treating Fuchs Endothelial Corneal Dystrophy (“FECD”) affecting the Descemet membrane of a patient's cornea, in a patient in need thereof, comprising:
- a) removing a central portion of the Descemet membrane from the patient's eye;
- b) topically administering to the patient's eye a therapeutically effective amount of ripasudil or a pharmaceutically acceptable salt thereof, from 2 to 4 times per day, for from 8-12 weeks;
- and
- c) tapering the therapeutically effective amount to zero over approximately two weeks.
1 more element
A method of treating Fuchs Endothelial Corneal Dystrophy (“FECD”) affecting the Descemet membrane of a patient's cornea, comprising:
- a) removing a central portion of the Descemet membrane from the patient's eye;
- and
- b) topically administering to the patient's eye a therapeutically effective amount of ripasudil or a pharmaceutically acceptable salt thereof for from 8 to 12 weeks;
- c) tapering the therapeutically effective amount to zero over approximately two weeks.
1 more element
A method of treating Fuchs Endothelial Corneal Dystrophy (“FECD”) affecting the Descemet membrane of a patient's cornea, comprising:
- a) removing a central portion of the Descemet membrane from the patient's eye;
- and
- b) topically administering to the patient's eye a therapeutically effective amount of ripasudil hydrochloride, in a concentration of about 0.4 mg/mL based on the weight of the free base excluding any hydration, in the absence of any preservatives, four times per day, for from 8 to 12 weeks;
- c) tapering the therapeutically effective amount to zero over approximately two weeks.
1 more element
Dependencies are inferred from the claim text.