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US 12,599,607 B2Granted
Pharmaceutical compositions comprising timolol
AssigneeNovaliq GmbH
InventorsFrank Löscher, Sonja Krösser, Diana Strehl, Bernhard Hauptmeier, Kirsten Eickhoff
Life of this patent
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Abstract
The present invention relates to pharmaceutical composition comprising the beta 1 (β1)-receptor blocker timolol and a liquid vehicle comprising a semifluorinated alkane. The pharmaceutical composition of the present invention may be useful for topical administration, for example ophthalmic topical administration and for use in the treatment of glaucoma, increased intraocular pressure, ocular hypertension and/or a symptom associated therewith.
Claims21
A pharmaceutical composition consisting of particles of timolol maleate and a liquid vehicle;
- wherein the particles consist of the timolol maleate, and wherein the particles are suspended in the liquid vehicle;
- wherein the liquid vehicle consists essentially of 1-perfluorohexyloctane and optionally a co-solvent;
- wherein at least 90% of the suspended particles of the timolol maleate have a size of not more than about 20 μm;
- wherein the concentration of the timolol maleate in the pharmaceutical composition corresponds to about 0.5% (w/v) of timolol, measured as the free base;
- and wherein the composition is formulated for topical ophthalmic administration.
2 more elements
Dependencies are inferred from the claim text.