Compositions and methods for preventing and treating headache through enhancing 2-arachydonyl glyerol activity
AssigneesArizona Board of Regents on Behalf of the University of Arizona, University of Washington
InventorsTally M. Largent-Milnes, Erika Liktor-Busa, Todd W. Vanderah, Nephi Stella
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Abstract
This invention relates generally to compositions and methods for preventing, reducing the occurrence of or treating a headache in a subject in need thereof. In particular, the present invention relates to methods for enhancing 2-arachydonyl glycerol (2AG) tone and reducing prostaglandin activity in a subject for purposes of preventing, reducing the occurrence of or treating a headache (e.g., a migraine headache) in a subject.
Claims5
A method comprising administering to a human subject suffering from a headache a pharmaceutical composition capable of enhancing arachidonoylglycerol (2AG) tone and/or inhibiting prostaglandin activity in the brain,
- wherein the human subject is suffering from a headache characterized with 1) decreased 2AG levels in the periaqueductal grey (PAG) brain region, and 2) unaltered anandamide (AEA) levels in the trigeminal ganglia (TG) brain region,
- wherein the pharmaceutical composition capable of enhancing 2AG tone and/or reducing prostaglandin activity in the mammal comprises MJN110 and KT182.
Dependencies are inferred from the claim text.