Methods and compositions for treating non-ERK MAPK pathway inhibitor-resistant cancers
AssigneeBiomed Valley Discoveries, Inc.
InventorsSaurabh Saha, Dean Welsch, Gary Decrescenzo, Jeffrey Roix
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Abstract
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which cancer is refractory or resistant to non-ERK MAPK pathway inhibitor therapy. Also provided are methods for identifying a subject having cancer who would benefit from therapy with an ERK inhibitor and methods for inhibiting phosphorylation of RSK in a cancer cell that is refractory or resistant to a non-ERK MAPK pathway inhibitor.
Claims8
A method for treating or ameliorating effects of a cancer selected from pancreatic cancer, papillary thyroid cancer, colorectal cancer, non-small cell lung cancer, ovarian cancer, endometrioid endometrial cancer or melanoma in a subject, comprising administering to the subject an effective amount of (i) BVD-523 (ulixertinib) that has a structure of
- or a pharmaceutically acceptable salt thereof, and (ii) SCH772984.
Dependencies are inferred from the claim text.