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US 12,599,590 B2Granted
Veterinary formulations comprising rapamycin and methods of using the same for treating animal disease
AssigneeTriviumVet DAC
InventorsTom Brennan, Louise Grubb, Liam Byrne, Stuart Fitzgerald
Life of this patent
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Abstract
The present disclosure provides veterinary formulations comprising rapamycin or rapalogs for administration to companion animals and methods of using the formulations to treat cardiac dysfunction, including hypertrophic cardiomyopathy, dilated cardiomyopathy, mitral valve disease, pressure-overload cardiac hypertrophy, cancer, effects of aging, inflammatory disease, and viral infection.
Claims15
A method for treating hypertrophic cardiomyopathy, dilated cardiomyopathy, mitral valve disease, or pressure-overload cardiac hypertrophy in companion animals, the method comprising:
- administering to the companion animal in need thereof a composition comprising;
- an intra-granular part comprising rapamycin, rapalog, or a salt thereof in a dispersion comprising a binder, and a polymer, an extra-granular part comprising a polymer, and a delayed release coating, wherein the composition is administered to the companion animal once per week at a dosing amount of the rapamycin, rapalog, or salt thereof from about 0.025 mg/kg to about 0.75 mg/kg.
Dependencies are inferred from the claim text.