Back to results
US 12,599,572 B2Granted
Solid lipid nanoparticles of curcumin
AssigneePunjab University Chandigarh
InventorsIndu Pal Kaur, Vandita Kakkar, Simarjot Kaur Sandhu, Tanvi Gupta
Life of this patent
Estimating the term…
Abstract
Provided herein is a process for preparing solid lipid nanoparticles of curcumin. Also provided herein are solid lipid nanoparticles of curcumin having a particle size in the range of 20-800 nm. The solid lipid nanoparticles of curcumin show a very high entrapment efficiency of curcumin in the range of 50-100% in terms of actual curcumin content of the formulation. The solid lipid nanoparticles of curcumin show increased efficacy of the curcumin.
Claims20
Solid lipid nanoparticles of curcumin, comprising
- a. a lipid phase comprising of curcumin, lipid or mixture of lipids selected from group consisting of glycerides and fatty acids, and a co-solvent,
- wherein curcumin is entrapped in the lipid phase in a soluble/amorphous form;
- b. an aqueous phase comprising water, curcumin, surfactant, and co-surfactant,
- wherein curcumin in the aqueous phase is in a solubilized form to prevent crystallization,
- wherein the co-solvent is selected from polyethylene glycol, PVP, PVA, glycerol,-diethylene glycol monoethyl ether, glycerol monocaprylocaprate, polyethylene glycol monostearate, hydrogenated vegetable glycerides, glyceryl citrate, glyceryl lactate, glyceryl lincolate, glyceryl oleate, polyglyceryl-4-cocoate, polyglyceryl-3-carprate and derivatives thereof, polyglyceryl-3-capoylate and derivatives thereof.
2 more elements
Dependencies are inferred from the claim text.