Thrombus removal systems and associated methods

A thrombus removal system, comprising:

• an elongated catheter device including:
• a distal portion configured to be positioned within a blood vessel of a patient, the distal portion comprising an inner wall forming an aspiration lumen, and an outer wall, and a fluid lumen formed in a space between the inner wall and the outer wall;
• a manifold formed near a distal end of the fluid lumen and the aspiration lumen, the manifold including a first fluid port and a second fluid port formed therein and surrounded by the manifold, the first fluid port having a first axis, the second fluid port having a second axis, wherein the first axis intersects with the second axis at a fluid intersection within the distal portion, the first fluid port and the second fluid port being configured to direct respective fluid streams along the first axis and the second axis that collide at the fluid intersection within the distal portion;
• a proximal portion configured to be positioned external to the patient, the aspiration lumen extending from the distal portion to the proximal portion;
• an aspiration mechanism positioned external to the patient and fluidly coupled with the aspiration lumen, the aspiration mechanism configured to reduce a pressure at the distal portion (a) to engage a thrombus therewith and/or (b) to draw the thrombus and/or thrombus fragments proximally;
• and
• a fluid delivery mechanism configured to supply fluid through the fluid lumen.