Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation

A method to confirm insertion, into cutaneous tissue, of a microneedle-based analyte-selective sensor, said method comprising:

• applying, by an excitation circuit of the analyte-selective sensor and after an attempted insertion into the cutaneous tissue of at least two electrodes of the analyte-selective sensor, a first electrical potential to the at least two electrodes;
• measuring, by a measurement circuit of the analyte-selective sensor, a resultant electrical value generated between the at least two electrodes through the cutaneous tissue;
• comparing the resultant electrical value to a range of values indicative of insertion of the at least two electrodes into the cutaneous tissue;
• and
• applying, by the excitation circuit of the analyte-selective sensor and responsive to the comparison indicating insertion of the at least two electrodes of analyte-selective sensor into the cutaneous tissue, a second electrical potential to the at least two electrodes,
• wherein the second electrical potential is greater than the first electrical potential and is used to measure an analyte concentration within physiological fluid.

A method to confirm insertion, into cutaneous tissue, of an analyte-selective sensor comprising a microneedle array, said method comprising:

• applying, by an excitation circuit of the analyte-selective sensor, a first electrical potential to at least two electrodes of the microneedle array following an attempted insertion of the microneedle array into the cutaneous tissue;
• measuring, by a measurement circuit of the analyte-selective sensor, a resultant electrical value generated between the at least two electrodes through the cutaneous tissue;
• comparing the resultant electrical value to a range of values indicative of insertion into the cutaneous tissue;
• and
• applying, by the excitation circuit of the analyte-selective sensor and responsive to the comparison indicating insertion of the microneedle array into the cutaneous tissue, a second electrical potential to the at least two electrodes,
• wherein the second electrical potential is greater than the first electrical potential and is used to measure an analyte concentration within physiological fluid.

A method of an analyte-selective sensor comprising a first microneedle with a first electrode and a second microneedle with a second electrode, said method comprising:

• applying, by an excitation circuit of the analyte-selective sensor and after an attempted insertion of the first and second microneedles into cutaneous tissue of a user, a first electrical potential to the first and second electrodes;
• measuring, by a measurement circuit of the analyte-selective sensor, a first resultant electrical value generated between the first and second electrodes through the cutaneous tissue;
• comparing the resultant electrical value to a range of values indicative of insertion of the first and second microneedles into the cutaneous tissue;
• providing, when the comparison indicates insertion of the first and second microneedles into the cutaneous tissue is not achieved, a direction to the user to apply a force to the analyte-selective sensor to attempt re-insertion of the analyte-selective sensor;
• applying, by the excitation circuit of the analyte-selective sensor and after the attempted re-insertion of the first and second microneedles into the cutaneous tissue of the user, a second electrical potential to the first and second electrodes;
• measuring, by the measurement circuit of the analyte-selective sensor, a second resultant electrical value generated between the first and second electrodes through the cutaneous tissue;
• comparing the resultant electrical value to the range of values indicative of insertion of the first and second microneedles into the cutaneous tissue;
• and
• applying, by the excitation circuit of the analyte-selective sensor and when the comparison indicates insertion of the first and second microneedles into the cutaneous tissue, a third electrical potential to the first and second electrodes,
• wherein the third electrical potential is greater than the first electrical potential and the second electrical potential.