Implantable micro-biosensor and method for operating the same

An implantable micro-biosensor for continuously monitoring a physiological parameter of an analyte in a body, comprising:

• a substrate having a first surface and a second surface opposite to said first surface, said first surface including a first sensing region for measuring a physiological parameter;
• a first working electrode including a first sensing section disposed on said first surface of said substrate and located at the first sensing region, said first sensing section being driven by a first potential difference so as to form a measuring region to measure a physiological signal in response to the physiological parameter of the analyte;
• at least one second working electrode disposed on said first surface of said substrate and including a second sensing section proximate to said first sensing section and located at the first sensing region, said second sensing section being driven by a second potential difference to form an interference-eliminating region that is in touch with a surrounding of said first sensing section and at least partially overlaps with said measuring region, so as to simultaneously consume an interfering substance in the body approaching said first and second sensing sections;
• at least one counter electrode disposed on said first or second surface of said substrate and including a silver-silver halide, so as to cooperate with said first working electrode to measure the physiological signal, to cooperate with said second working electrode to consume the interfering substance, and to selectively cooperate with said first or second working electrode so as to be driven to regenerate silver halide,
• wherein a surface material of said first sensing section includes a first conductive material, and a surface material of said second sensing section includes a second conductive material different from said first conductive material,
• wherein said first working electrode is driven by said first potential difference so as to permit said first conductive material to have a first sensitivity that is responsive to the product,
• wherein said second working electrode is driven by said second potential difference so as to permit said second conductive material to have a second sensitivity that is responsive to the product and that is smaller than said first sensitivity,
• wherein said first sensing section and the second sensing section are aligned in a same plane on the substrate, said second sensing section extends along and is spaced apart from at least a portion of a periphery of said first sensing section, and a ratio of said portion of said periphery of said first sensing section to a total periphery of said first sensing section ranges from 30% to 100%, and
• wherein at least three sides of said first sensing section are surrounded by and spaced apart from said second sensing section by a distance;
• and
• a chemical reagent layer covering at least a portion of said first conductive material of said first sensing section and reacting with the analyte to generate a product.