Device, method and systems for providing imaging of one or more aspects of blood perfusion

System for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject, said system comprising:

• an illumination unit configured to emit a narrow radiation beam of electromagnetic radiation;
• an optical diffuser configured to diffuse the electromagnetic radiation emitted by the illumination unit to illuminate the skin region of the subject homogenously and/or by a patterned illumination either by a patterned illumination for radial imaging or by a homogenous illumination for widefield imaging;
• an imaging unit configured to detect the electromagnetic radiation transmitted through or reflected from the skin region of the subject and to derive data streams from the detected electromagnetic radiation;
• and
• a device for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject according to any one of the preceding claims from the obtained data streams, wherein the device is configured to obtain a first data stream derived from a radial imaging of the skin region and a second data stream derived from a widefield imaging of the skin region, wherein both the first data stream and the second data stream are acquired at substantially the same wavelength.

Method for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject, said method comprising the steps of:

• obtaining data streams derived from detected electromagnetic radiation transmitted through or reflected from the skin region, said data streams comprising a data signal per skin pixel for a plurality of skin pixels of the skin region, wherein a first data stream is derived from radial imaging of the skin region and a second data stream is derived from widefield imaging of the skin region, wherein both the first data stream and the second data stream are acquired at substantially the same wavelength;
• determining, per skin pixel or group of skin pixels, from the data signals of the first data stream and the second data stream, optical depth indices, ODIs, by dividing, per skin pixel or group of skin pixels, data signals of the first data stream by data signals of the second data stream, wherein the ODIs are indicative of the depth of the blood flow within the skin region at the skin pixels or groups of skin pixels;
• creating an ODI image map of the skin region including the plurality of skin pixels from the determined ODIs;
• creating an amplitude image map of the skin region including the plurality of skin pixels from amplitudes of the data signals of the second data stream;
• and
• correcting the amplitude image map by correcting, per skin pixel or group of skin pixels, the amplitudes of the data signals of the second data stream by the determined ODIs.