Treatment of tumors with miRNA targeting CDK4/CDK6
AssigneeInstitute for Cancer Research Institute of Fox Chase Cancer Center
InventorsAmriti R. Lulla, Wafik S. El-Deiry
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Abstract
The present disclosure provides miRNA mimics targeting CDK4 and/or CDK6, and compositions comprising the same. Methods for the treatment of tumors, including but not limited to colon cancer, comprising administering a modified oligonucleotide comprising a miRNA are also disclosed herein.
Claims4
A method for modulating expression of CDK4 and/or CDK6 in a tumor or cancer cell, the method comprising contacting a tumor or cancer cell selected from a colorectal cancer cell, a pancreatic cancer cell, and a melanoma cell with one or more oligonucleotides consisting of 15 to 40 linked nucleobases, or a salt thereof, wherein the one or more oligonucleotides comprises a nucleobase sequence that is at least 95% identical to a nucleobase sequence selected from SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:4, and wherein said contacting reduces the expression of CDK4 and/or CDK6 in the cell.
Dependencies are inferred from the claim text.