US 12,595,315 B2 · Monoclonal antibody of matrix metalloproteinase-1, detection kit and detection method thereof

Abstract

Provided is a monoclonal antibody of matrix metalloproteinase 1. The monoclonal antibody has a heavy chain variable region with an amino sequence comprising i) CDR1 selected from the group consisting of SEQ ID NOs: 1, 7 and 13, ii) CDR2 selected from the group consisting of SEQ ID NOs: 2, 8 and 14, and iii) CDR3 selected from the group consisting of SEQ ID NOs: 3, 9 and 15. The monoclonal antibody also has a light chain variable region with an amino sequence comprising i) CDR1 selected from the group consisting of SEQ ID NOs: 4, 10 and 16, ii) CDR2 selected from the group consisting of SEQ ID NOS: 5, 11 and 17, and iii) CDR3 selected from the group consisting of SEQ ID NOs: 6, 12 and 18. A polynucleotide, a detection kit and a detection method are also provided as well.

Claims12

Dependent claims

A monoclonal antibody, comprising:

a monoclonal antibody A, wherein a heavy chain variable region sequence of the monoclonal antibody A comprises amino acid sequences of SEQ ID NOs:
1, 2, and 3, and a light chain variable region sequence of the monoclonal antibody A comprises amino acid sequences of SEQ ID NOs:
4, 5, and 6;
a monoclonal antibody B, wherein a heavy chain variable region sequence of the monoclonal antibody B comprises amino acid sequences of SEQ ID NOs:
7, 8, and 9, and a light chain variable region sequence of the monoclonal antibody B comprises amino acid sequences of SEQ ID NOs:
10, 11, and 12;
or
a monoclonal antibody C, wherein a heavy chain variable region sequence of the monoclonal antibody C comprises amino acid sequences of SEQ ID NOs:
13, 14, and 15, and a light chain variable region sequence of the monoclonal antibody C comprises amino acid sequences of SEQ ID NOs:
16, 17, and 18.

7 more elements

Dependencies are inferred from the claim text.

Monoclonal antibody of matrix metalloproteinase-1, detection kit and detection method thereof

Life of this patent

Monoclonal antibody of matrix metalloproteinase-1, detection kit and detection method thereof

Life of this patent

Abstract

Claims12