CD133-binding agents and uses thereof
AssigneesThe Governing Council of the University of Toronto, McMaster University
InventorsJason Moffat, Jarrett Adams, Guohua Pan, Sachdev Sidhu, Rashida Williams, Xiaoyu Zhang, Sheila K. Singh, Parvez Vora, Chitra Venugopal
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Abstract
This disclosure is directed to novel CD133-binding agents. The disclosure is also directed to uses of novel CD133-binding agents for detecting CD133-expressing cells and/or quantitating levels of cellular CD133 expression, for targeting CD133-expressing cells, for decreasing levels of CD133 in CD133-expressing cells and for treating or preventing cancer.
Claims27
An antibody or an antigen binding fragment thereof that specifically binds to a CD133 polypeptide, wherein said antibody or antigen binding fragment thereof comprises a light chain variable domain comprising complementarity determining regions (CDRs) comprising SEQ ID NOs:
- 6, 7, and 8 and a heavy chain variable domain comprising CDRs comprising SEQ ID NOs:
- 9, 10, and 11.
Dependencies are inferred from the claim text.