Anti-B7H3 antibody and use thereof
AssigneeGuangzhou Bio-Gene Technology Co., Ltd
InventorsMin Luo, Guangchao Li, Zhao Zhou, Xuejun Wang
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Abstract
Provided are an anti-B7H3 antibody and the use thereof. A variable region of the antibody comprises amino acid sequences as shown in SEQ ID NOs: 25-39. The anti-B7H3 antibodies 26B6, 6F7, 2B8, and 23H1 have a significant binding capability to B7H3, can not only bind to purified or free B7H3 protein, but also can bind to B7H3 protein on a cell surface; and after humanized modification, the affinity between the antibody and B7H3 is further improved, and the antibody has important application prospects in clinical diagnosis and/or treatment of B7H3-positive tumors.
Claims11
An anti-B7H3 antibody or antigen-binding fragment thereof, comprising heavy chain variable domain CDRs:
- CDRH1, CDRH2, and CDRH3;
- and light chain variable domain CDRs:
- CDRL1, CDRL2, and CDRL3;
- wherein CDRH1 is selected from SEQ ID NOs:
- 17, 18, 19, or 20;
- wherein CDRH2 is selected from SEQ ID NOs:
- 9, 10, 11, or 12;
- wherein CDRH3 is selected from SEQ ID NOs:
- 1, 2, 3, or 4;
- wherein CDRL1 is selected from SEQ ID NOs:
- 21, 22, 23, or 24;
- wherein CDRL2 is selected from SEQ ID NOs:
- 13, 14, 15, or 16;
- and
- wherein CDRL3 is selected from SEQ ID NOs:
- 5, 6, 7, or 8.
Dependencies are inferred from the claim text.