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US 12,595,259 B2Granted
Aminopyridine compound
AssigneeZhuhai United Laboratories Co., Ltd.
InventorsPeng Li, Chong Su, Xiaolin Li, Zhi Luo, Haiying He, Guoping Hu, Jian Li, Shuhui Chen
Life of this patent
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Abstract
An aminopyridine compound that may be used as an aldehyde trapping agent, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
Claims18
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,
- wherein,
- L is selected from —O— and —(CR4R5)n—;
- R1 is selected from —C1-6 alkyl- and —C3-5 cycloalkyl-, and the —C1-6 alkyl- and —C3-5 cycloalkyl- are optionally substituted by 1, 2 or 3 Ra;
- ring A is selected from phenyl, pyridyl and 5-membered heteroaryl, and the phenyl, pyridyl and 5-membered heteroaryl are optionally substituted by 1, 2 or 3 R3;
- and when ring A is selected from phenyl and pyridyl, R2 is selected from —C5-6 alkyl- and —C3-5 cycloalkyl-, and the —C5-6 alkyl- and —C3-5 cycloalkyl- are optionally substituted by 1, 2 or 3 Rb;
- when ring A is selected from 5-membered heteroaryl, R2 is selected from —C1-6 alkyl- and —C3-5 cycloalkyl-, and the —C1-6 alkyl- and —C3-5 cycloalkyl- are optionally substituted by 1, 2 or 3 Rc;
- R3 is selected from H, F, Cl, Br, I and CH3;
- R4 and R5 are each independently selected from H and CH3;
- n is selected from 0, 1 and 2;
- Ra, Rb and Rc are each independently selected from F, Cl, Br and I;
- the “5-membered heteroaryl” comprises 1, 2, 3 or 4 heteroatoms or heteroatom groups independently selected from —O—, —NH—, —S— and N, respectively.
8 more elements
A compound represented by the following formula or a pharmaceutically acceptable salt thereof, wherein the compound is selected from any one of the following compounds:
Dependencies are inferred from the claim text.