At-home kit for prostate cancer screening and other diseases

A kit for collection of biofluid from a patient and preservation of any DNA and/or RNA contained in the collected biofluid, comprising:

• a wipe composed of fibers for absorbing a preselected biofluid, the wipe being selected from a fiber-containing paper or a fiber-containing fabric;
• a rigid re-sealable tube configured to contain the impregnated wipe therein;
• a re-sealable bag;
• instructions on how to impregnate the wipe with the preselected biofluid and seal it in the re-sealable bag;
• a return envelope configured to receive therein the re-sealable bag containing the impregnated wipe,
• wherein the re-sealable tube is sealed in the re-sealable bag,
• wherein the wipe has a slit along one edge of the wipe sized to be trapped between a lid on the rigid re-sealable tube and the tube itself during an extraction procedure of DNA/RNA from the collected biofluid so the wipe is draped over a lip of the tube and hangs down into the interior of the tube with a bottom edge of the wipe spaced from the bottom of the tube, and
• wherein the wipe is impregnated with an SDS solution having a concentration of about 0.01% v/v to about 2% v/v SDS acting as a general nuclease inhibitor for the preservation of the DNA and/or RNA contained in the absorbed biofluid, an EDTA solution having a concentration from about 1 mM to about 5 mM EDTA for inhibiting RNAse/DNAse activity and inducing RNA/DNA binding to the fibers of the wipe, and a sodium azide solution having a concentration of about 0.01% to about 0.2% sodium azide for preserving protein biomarkers and preventing growth of bacteria and mold.