US 12,594,435 B2Granted

Interstitial photodynamic therapy

AssigneeSimphotek, Inc.

InventorsKarl Beeson, Evgueni Parilov, Mary Potasek

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Abstract

A method of administering interstitial photodynamic therapy to a target region of a patient may include receiving information associated with the target region, an initial photosensitizer concentration, a plurality of initial photosensitizer photokinetic rate parameters, and a threshold treatment dose for a photosensitizer, the threshold treatment dose being a threshold photodynamic therapy-dose or a threshold reactive oxygen species dose. A location in the target region for inserting at least one interstitial treatment fiber to deliver the treatment light, and initial values for treatment light transmission is determined. Computational spatial elements are determined for the target region and for the location of emitting surfaces of the at least one interstitial treatment fiber, and a light fluence rate for delivering treatment light to each of the computational spatial elements. A treatment dose is determined based on the light fluence rate, the plurality of photosensitizer photokinetic rate parameters, and a photokinetic rate equation.

Claims20

Dependent claims

A system for delivering a treatment dose to a target region of a patient for interstitial photodynamic therapy, the system comprising:

a treatment light source coupled to at least one interstitial treatment fiber;
a diagnostic light source coupled to at least one interstitial diagnostic fiber;
at least one interstitial detector to detect diagnostic light generated by the diagnostic light source and/or treatment light generated by the treatment light source and/or photosensitizer fluorescence generated by the diagnostic light source or the treatment light source;
and
a processor configured to:
receive information associated with the target region, an initial photosensitizer concentration, a plurality of initial photosensitizer photokinetic rate parameters, and a threshold treatment dose for a photosensitizer, the threshold treatment dose being a threshold photodynamic therapy-dose or a threshold reactive oxygen species dose;
determine a location in the target region for inserting the at least one interstitial treatment fiber to deliver the treatment light;
determine initial values for therapeutic light power, and light emitting length and therapeutic treatment time for the at least one interstitial treatment fiber;
determine computational spatial elements for the target region and for the location of emitting surfaces of the at least one interstitial treatment fiber, and a fluence rate for delivering treatment light to each of the computational spatial elements;
determine a treatment dose based on the fluence rate, the plurality of photosensitizer photokinetic rate parameters, and a photokinetic rate equation;
and
generate a command for controlling the treatment light source to deliver via the at least one interstitial treatment fiber the treatment dose to the target region,
wherein the processor is further configured to determine a value of one or both of a portion of interior volume and a portion of a boundary region of the target region to which the delivered treatment dose is greater than the threshold treatment dose.

10 more elements

A system for planning an interstitial photodynamic therapy, the system comprising:

a non-transitory computer-readable memory to store instructions;
a processor to execute the instructions stored on the memory, the instructions causing the processor to:
receive information associated with the target region, an initial photosensitizer concentration, a plurality of initial photosensitizer photokinetic rate parameters, and a threshold treatment dose for a photosensitizer, the threshold treatment dose being a threshold photodynamic therapy-dose or a threshold reactive oxygen species dose,
determine a location in the target region for inserting at least one interstitial treatment fiber to deliver the treatment light,
determine initial values for therapeutic light power, and light emitting length and therapeutic treatment time for the at least one interstitial treatment fiber,
determine computational spatial elements for the target region and for the location of emitting surfaces of the at least one interstitial treatment fiber, and a fluence rate for delivering treatment light to each of the computational spatial elements, and
determine a treatment dose based on the fluence rate, the plurality of photosensitizer photokinetic rate parameters, and a photokinetic rate equation;
and
at least one spectrometer coupled to the at least one interstitial detector to detect one or more of treatment light intensity, diagnostic light intensity and fluorescence light intensity generated by a treatment light source or a diagnostic light source.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/451,308Filed 17 Aug 2023 · continuation
Priority: 18 Aug 2020
Published: US 2023/0238099 A17 Dec 2023
Granted: 7 Apr 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61N 5/062
Apparatus adapted for a specific treatment: photodynamic therapy, i.e. excitation of an agent
A61N 5/0601
Using light: apparatus for use inside the body
G16H 20/10
ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient…:…
A61N 5/067
Using light: using laser light

Family

Application63/066,895Us provisional application · filed 18 Aug 2020
PCT/US2021/045341Parent of this continuation · filed 10 Aug 2021
US 2023/0390578 A1Pre-grant publication · published 7 Dec 2023
Application18/041,079Parent of this continuation
US 11,771,916 B2Parent of this continuation
US 2023/0238099 A1Published application
US 12,594,435 B2This patent

From the US filing history. Foreign family members aren’t listed.

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