US 12,594,339 B2 · Lipid prodrugs of JAK inhibitors and uses thereof

Abstract

The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Claims7

Dependent claims

A compound of Formula VII-b:

or a pharmaceutically acceptable salt thereof, wherein:
R1 and R2 are each —C(O)R3;
each R3 is independently a saturated or unsaturated, straight or branched, optionally substituted C1-37 hydrocarbon chain;
each R4 and R5 is independently hydrogen or C1-4 alkyl optionally substituted with 1, 2, 3, 4, 5, or 6 deuterium or halogen atoms;
wherein at least one R4 is a C1-4 alkyl.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/310,871Filed 28 Feb 2020 · us provisional application

Priority

28 Feb 2019

Published

US 2022/0125933 A128 Apr 2022

Granted

7 Apr 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 47/542
The modifying agent being an organic compound: carboxylic acids, e.g. a fatty acid or an amino acid
A61K 31/437
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring…
A61K 31/4985
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: pyrazines or piperazines…

Lipid prodrugs of JAK inhibitors and uses thereof

Life of this patent

Lipid prodrugs of JAK inhibitors and uses thereof

Life of this patent

Abstract

Claims7