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US 12,594,337 B2Granted
Human serum albumin in formulations
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsDorothy Kim, Michael Marlow
Life of this patent
Estimating the term…
Abstract
Drug formulations and methods for removing, reducing, or preventing the formation of fatty acid particles in drug formulations are provided. In particular, this disclosure sets forth the inclusion of human serum albumin in an active pharmaceutical agent formulation, such as an antibody drug formulation, at an effective concentration for reducing fatty acid particle formation and solubilizing fatty acid particles.
Claims14
A formulation, comprising:
- an active pharmaceutical agent, a polysorbate, at least one lipase, and at least about 5.5 mg/mL human serum albumin, wherein said formulation is capable of forming fatty acid particles, wherein said human serum albumin reduces said formation of fatty acid particles, and wherein said active pharmaceutical agent is not human serum albumin.
Dependencies are inferred from the claim text.