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US 12,594,334 B2Granted
ETAR antibody, and pharmaceutical compositions and use thereof
AssigneeGmax Biopharm LLC
InventorsCheng Zhang, Kesuo Fan, Yong Guo, Chenjiang Yao, Hua Zhang, Xiaofeng Wang, Shuqian Jing
Life of this patent
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Abstract
Provided herein are a stable solution formulation of an ETAR antibody, and use thereof in treating, preventing, or alleviating one or more symptoms of pulmonary arterial hypertension or one or more symptoms of cancer of a reproductive organ.
Claims21
A stable pharmaceutical solution formulation of an ETAR antibody, comprising an ETAR antibody and a buffer, wherein the formulation has a pH approximately ranging from 5 to 7;
- and wherein the ETAR antibody comprises light chain CDR1 amino acid sequence:
- SEQ ID NO:
- 8;
- light chain CDR2 amino acid sequence:
- SEQ ID NO:
- 32;
- light chain CDR3 amino acid sequence:
- SEQ ID NO:
- 50;
- heavy chain CDR1 amino acid sequence:
- SEQ ID NO:
- 70;
- heavy chain CDR2 amino acid sequence:
- SEQ ID NO:
- 92;
- and heavy chain CDR3 amino acid sequence:
- SEQ ID NO:
- 116.
15 more elements
Dependencies are inferred from the claim text.