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US 12,594,326 B2Granted
Compositions of GLP-1 peptides and preparation thereof
AssigneeNovo Nordisk A/S
InventorsThomas Kvistgaard Vilhelmsen, Helle Eliasen, Tue Hansen
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Abstract
The invention relates to pharmaceutical compositions comprising a first type of granules and a second type of granules, wherein said first type of granules comprises a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and no GLP-1 peptide, and wherein said second type of granules comprises a GLP-1 peptide and no salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid, as well as the intermediate granules, processes for the preparation of the granules and compositions, and use thereof in medicine.
Claims11
A pharmaceutical composition comprising a first type and a second type of granules,
- wherein the first type of granules comprises at least 70% (w/w) of sodium N-(8-(2-hydroxybenzoyl)amino)caprylic acid (SNAC) and less than 10% (w/w) of a lubricant, and
- wherein the second type of granules comprises semaglutide, at least 15% (w/w) of a filler, and less than 40% (w/w) of a binder.
Dependencies are inferred from the claim text.