Back to results
US 12,594,322 B2Granted
Liquid composition comprising protein
AssigneeSamsung Bioepis Co., Ltd.
InventorsInae Kim, Soyun Jung, Jaemin Lee, Hun Joo Lee, Yongkook Kim
Life of this patent
Estimating the term…
Abstract
The present invention relates to a protein-stabilized liquid formulation and provides: a composition for protein stabilization, the composition including a stabilizer and a surfactant and not including a buffer; a protein liquid composition including the composition for stabilization and a protein; and a method of producing a protein-stabilized liquid composition which uses the composition for stabilization.
Claims12
A liquid composition comprising:
- (1) 5 mg/ml to 300 mg/ml of aflibercept;
- (2) a stabilizer comprising a sugar;
- and
- (3) a surfactant,
- wherein the pH of the liquid composition is in a range of 4 to 8, and
- wherein the liquid composition does not comprise any of the buffers selected from the group consisting of phosphoric acid, acetic acid, citric acid, succinic acid, carbonic acid, histidine, aspartic acid, and glutamic acid, or a pharmaceutically acceptable salt of the buffer.
3 more elements
A liquid composition comprising:
- (1) aflibercept;
- (2) a stabilizer comprising a sugar;
- and
- (3) a surfactant,
- wherein the pH of the liquid composition is in a range of 5.7 to 6.7, and
- wherein the liquid composition does not comprise any of the buffers selected from the group consisting of phosphoric acid, acetic acid, citric acid, succinic acid, carbonic acid, histidine, aspartic acid, and glutamic acid, or a pharmaceutically acceptable salt of the buffer.
3 more elements
Dependencies are inferred from the claim text.