US 12,594,284 B2 · Combination of micronutrients to stimulate the endogenous production of hydrogen sulfide (H2S)

Abstract

The present invention relates to pharmaceutical, dietary and/or food compositions exerting the ability to activate the endogenous production of hydrogen sulfide (H2S) so to feed the redox buffer capacity and to boost the natural ability to compensate both oxidative and reductive stress. The invention further relates to the use of the aforementioned compositions to correct signs of metabolic derangements such as: oxy-redox imbalances including reductive stress, mitochondrial dysfunction and bioenergetics, insulin resistance, endothelial dysfunction and hyperhomocysteinemia. Accordingly, the composition of the present invention can be used as a medicament for the treatment of hypertension, atherosclerosis and cardiovascular disease, erectile dysfunction, viral infections and inflammatory lung injuries, diabetes and PCOS, autoimmune diseases, neurodegeneration, repeated implantation failure and repeated miscarriage and infertility in both men and women.

Claims5

Dependent claims

A combination comprising:

a) L-cystine in amounts ranging from 40 to 60% by weight;
b) taurine and/or the pharmaceutically acceptable salts thereof in amounts ranging from 40 to 60% by weight;
c) pyridoxal-5-phosphate and/or the pharmaceutically acceptable salts thereof in amounts ranging from 0.1 to 5% by weight;
wherein said the percentages are with respect to the sum of components a), b) and c).

1 more element

Dependencies are inferred from the claim text.

Facts

Application

17/996,606Filed 3 May 2021

Priority

IT 1020200000097004 May 2020

Published

US 2023/0172954 A18 Jun 2023

Granted

7 Apr 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification26 codes

A61K 31/675
Phosphorus compounds: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/2009
Excipients; Inactive ingredients: inorganic compounds
A61K 9/2013
Excipients; Inactive ingredients: organic compounds, e.g. phospholipids, fats

Combination of micronutrients to stimulate the endogenous production of hydrogen sulfide (H2S)

Life of this patent

Combination of micronutrients to stimulate the endogenous production of hydrogen sulfide (H2S)

Life of this patent

Abstract

Claims5