Composition for preventing or treating TNF-α-related disease, comprising hydroflumethiazide as active ingredient

A method for treating a tumor necrosis factor-α (TNF-α)-related disease in a subject in need thereof, the method comprising administering, to the subject, an effective amount of a composition comprising hydroflumethiazide or a pharmaceutically acceptable salt thereof as an active ingredient,

• wherein the TNF-α-related disease is synovium proliferation, bone destruction, cartilage damage, arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, multiple sclerosis, sepsis, a respiratory disease, vasculitis, Behcet's disease, type 1 diabetes, systemic lupus erythematosus, adult-onset Still's disease, polymyositis, dermatomyositis, Wegener's granulomatosis, or a combination thereof, and
• wherein the treatment of the TNF-α-related disease is delaying progress of the TNF-α-related disease, or improving or beneficially changing symptoms of the TNF-α-related disease.