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US 12,594,274 B2Granted
Method for preparing a crystalline form of rabeximod
AssigneeGulch Pharma AB
InventorUlf Björklund
Life of this patent
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Abstract
The present invention relates to a process for preparing 9-Chloro-2,3-dimethyl-6-(N,N-dimethylaminoethylamino-2-oxoethyl)-6H-indolo-[2,3-b]quinoxaline, wherein said process is suitable for large scale synthesis.
Claims17
A process for preparing 9-chloro-2,3-dimethyl-6-(N,N-dimethylaminoethylamino-2-oxoethyl)-6H-indolo-[2,3-b]quinoxaline (rabeximod) or a salt thereof, wherein the process comprises the step of:
- reacting a solution or suspension of 9-chloro-2,3-dimethyl-6H-indolo[2,3-b]quinoxaline in the presence of an aqueous base sufficiently strong to deprotonize the indole N—H, with 2-chloro-N-(2-dimethylaminoethyl) acetamide or a salt thereof to obtain rabeximod or a salt thereof.
Dependencies are inferred from the claim text.