Combination therapy for cancer
AssigneeHealth Research, Inc.
InventorsScott I. Abrams, Sean H. Colligan
Life of this patent
Estimating the term…
Abstract
Provided are methods for treatment of cancer. The method comprises administering to an individual who has cancer a combination of treatment to reduce MDSC burden and immune therapy. For example, an individual may be administered brequinar and an immune checkpoint inhibitor. This disclosure provides a method for redirecting early myeloid precursors away from generating MDSCs thereby reducing MDSC burden.
Claims6
A method for alleviation of acute and chronic signs and symptoms associated with a cancer selected from a group consisting of breast, lung, renal, colorectal, cervical, gastric, ovarian, prostate, pancreatic cancer, or melanoma, the method comprising administering an anti-PD-1 antibody to the individual diagnosed with a said cancer, the method further comprising administering brequinar to the individual to inhibit development of myeloid-derived suppressor cells (MDSC) burden by reducing the frequency of granulocyte progenitors and increasing the frequency of monocyte progenitors in bone marrow of the individual.
Dependencies are inferred from the claim text.